Neurodegeneration Research Database

Research projects

Principal Investigator/ Researchers:
Eilis Dowd
Deirdre Hoban
Disease Area:
Parkinson's Disease and related disorders
Field of Research:
Basic/Discovery Research
Institution:
NUI Galway
Start year:
2012
Project Completed:
Yes
Funding body:
Irish Research Council
Recruiting Research Participants?:
No
Principal Investigator/ Researchers:
Eilis Dowd
Ruth Concannon
Disease Area:
Parkinson's Disease and related disorders
Field of Research:
Basic/Discovery Research
Institution:
NUI Galway
Start year:
2012
Project Completed:
Yes
Funding body:
Health Research Board
Recruiting Research Participants?:
No

The successful treatment of memory impairments and neurodegenerative disorders critically depends on our understanding of the storage and recollection of memory episodes. Specifically, an understanding of the interaction between amnesic and neurodegenerative syndromes would aid the development of effective treatments. One of the key questions in neuroscience is: how do brain networks encode experience-dependent memory? Answering this question will give us a universal tool to treat multiple brain disorders. The anatomical focus of my current research interests is the interaction between limbic, basal forebrain and nigro-striatal circuits as a possible candidate for interregional coordination of spatial navigation and context-dependent components of episodic memory. I plan to examine if 1) neuromodulation from cholinergic neurons in forebrain and pontine tegmentum and 2) neuromodulation from dopaminergic and GABA-ergic neurons from ventral tegmental area (VTA) and substantia nigra can regulate the properties of spatial experience-dependent spatial navigation to guide behaviour. Understanding the fundamental principles of this inter-regional signal processing will allow me to address my next goal: to apply pharmacological, electrophyiosological and genetic tools to treat memory and movement disorders. The cellular response to cholinergic and dopaminergic neurotransmitters in the hippocampal region is largely explored, but little is known about the optimising effect of extrinsic manipulation of the neuromodulatory projections on the encoding properties of hippocampal neurons and mnemonic function of the limbic system. Therefore, the present proposal addresses two broad questions: 1) Can we enhance the hippocampal spatial representation by activation of the cholinergic/dopaminergic systems? 2) Should medial temporal lobe amnesia and depression be regarded as independent syndromes, or are they interlinked?

Principal Investigator/ Researchers:
Marian Tsanov
Disease Area:
Dementia (including Alzheimer's Disease and other dementias)
Field of Research:
Basic/Discovery Research
Institution:
Trinity College Dublin
Start year:
2013
Project Completed:
No
Funding body:
Wellcome Trust
Recruiting Research Participants?:
No
Principal Investigator/ Researchers:
Eilis Dowd
Kiah McCabe
Disease Area:
Parkinson's Disease and related disorders
Field of Research:
Basic/Discovery Research
Institution:
NUI Galway
Start year:
2013
Project Completed:
Yes
Funding body:
Irish Research Council
Recruiting Research Participants?:
No

The overall aim of this research is to examine the effect of regular exercise on 1) Adult hippocampal neurogenesis 2) Cognitive performance in hippocampus-dependent memory tasks 3) Microglial activation and neuroinflammatory profile using the transgenic mouse model of Alzheimer’s Disease [amyloid precursor protein (APP)SWE/presenilin-1 (PS-1)]

Principal Investigator/ Researchers:
Dr. Aine Kelly
Sinead Ryan
Disease Area:
Dementia (including Alzheimer's Disease and other dementias)
Field of Research:
Basic/Discovery Research
Institution:
Trinity College Dublin
Start year:
2014
Project Completed:
No
Funding body:
Irish Research Council
Recruiting Research Participants?:
No
Principal Investigator/ Researchers:
Eilis Dowd
Niamh Moriarty
Disease Area:
Parkinson's Disease and related disorders
Field of Research:
Basic/Discovery Research
Institution:
NUI Galway
Start year:
2014
Project Completed:
Yes
Funding body:
Irish Research Council
Recruiting Research Participants?:
No

To develop and assess the feasibility of a theoretically-informed, evidence-based and sustainable intervention to rationalise antipsychotic prescribing in nursing home residents with dementia.

Principal Investigator/ Researchers:
Dr. Kieran Walsh
Prof. Stephen Byrne
Prof. John Browne
Dr. Jenny Mc Sharry
Dr. Suzanne Timmons
Disease Area:
Dementia (including Alzheimer's Disease and other dementias)
Field of Research:
Clinical Research
Institution:
University College Cork (UCC)
Start year:
2014
Project Completed:
Yes
Funding body:
Atlantic Philanthropies,Health Research Board,SPHeRE (Structured Population and Health-Services Research Education) programme (Grant No. SPHeRE/2013/1.)
Recruiting Research Participants?:
No
Principal Investigator/ Researchers:
Eilis Dowd
Abhay Pandit
Una FotzGerald
Disease Area:
Parkinson's Disease and related disorders
Field of Research:
Basic/Discovery Research
Institution:
NUI Galway
Start year:
2016
Project Completed:
No
Funding body:
European Union
Recruiting Research Participants?:
No

The aim is to evaluate the utility of a Connected Health model in supporting people with dementia and their carergivers in sustaining the patient at home. We propose that the CH model allows enhanced information- sharing between patient, carergiver and healthcare team, enabling streamlined clinical management, empowering the caregiver and enhancing the ability of the caregiver/patient dyad to cope. We hypothesise that this model offers benefits over usual care as measured by indicators of caregiver and health professional satisfaction, caregiver strain, quality of life, patient outcomes.

Principal Investigator/ Researchers:
Dr. Catherine Blake
Dr. Laura Mackey
Dr. Estefanía Guisado
Fiona Curran
Disease Area:
Dementia (including Alzheimer's Disease and other dementias)
Field of Research:
Connected Health
Institution:
University College Dublin (UCD)
Start year:
2016
Project Completed:
No
Funding body:
Health Research Board
Recruiting Research Participants?:
No
Principal Investigator/ Researchers:
Eilis Dowd
Rachel Kelly
Disease Area:
Parkinson's Disease and related disorders
Field of Research:
Basic/Discovery Research
Institution:
NUI Galway
Start year:
2017
Project Completed:
No
Funding body:
Irish Research Council
Recruiting Research Participants?:
No