Researcher members

Dr Aideen Sullivan

Senior Lecturer in Neuroscience | University College Cork, Department of Anatomy and Neuroscience

+ 353 21 4205427
Broad research area Basic Science Research | Clinical Research
Research interests Parkinson’s disease (Neuroprotective therapies, Stem Cell Therapies, Biomarkers, Animal Models, In Vitro Models, Neuropathological Mechanisms)

Dr Barry Boland

Lecturer in Pharmacology and Principal Investigator | University College Cork

021-4205977
Broad research area Basic Science Research | Clinical Research
Research interests To develop disease modifying drugs for treating age-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, we must identify and prevent the causative factors of their early pathogenesis. My research interest is focused on understanding how an excessive accumulation of intracellular metabolites (e.g. proteins, lipids, polysaccharrides and RNA) within the endosomal-autophagic-lysosomal (EAL) system, is a major contributing factor to neurodegenerative stress. Through translational research collaborations with clinicians, we aim to identify biomarkers of this specific pathology in patient biosamples, which can be used to develop future diagnostics and therapeutic treatments. Specific Research Projects: (i) Biomarker assays and remediation therapies for endosomal-autophagic-lysosomal dysfunction. (ii) Relevance of storage diseases to Alzheimer’s disease and Parkinson's disease. (iii) Impact of age-related osmotic stress on neuronal catabolic flux.

Dr Caroline Herron

Senior Lecturer | University College Dublin, School of Biomolecular and Biomedical Sciencees

017166774
Broad research area Basic Science Research
Research interests Main interest are in alterations in synaptic function and synaptic plasticity in models of Alzheimer's disease. Synaptic plasticity (long-term potentiation ; LTP) linked to memory is known to be reduced in transgenic mice that express FAD mutations. In addition amyloid derived diffusible ligands which are synthetic forms of oligomeric beta amyloid also disrupt LTP in the hippocampus. We have investigated how potential therapeutic agents including Il1beta- receptor antagonist, JNK inhibitors, L-type calcium channel blockers, peroxisome proliferator activated receptor agonists (PPARg), simvastatin and more recently cannabidiol (the non-psychoactive component of cannabis) can attentuate the effects of beta amyloid and also reverse deficits in LTP in transgenic mouse models. Techniques: Brain slice electrophysiology; Western blot quantification of beta amyloid and associated alterations in signalling proteins; cell viability assays; Elisa.

Dr Catherine Hughes

Lecturer Human Nutrition | Ulster University

+44 (0) 2870123516
Broad research area Population, Social and Connected Health Research
Research interests - role of nutrition, lifestyle and environment factors on cognitive decline and dementia - B-vitamins, 1-Carbon metabolism and age-related disease

Dr Charlotte Neville

Research Fellow (Centre for Ageing Research and Development in Ireland) | Centre for Public Health, Queen's University Belfast, Institute of Pathology Ground Floor, Grosvenor Road, Belfast, BT12 6BJ

02890632764
Broad research area Population, Social and Connected Health Research
Research interests Diet, retinal microvascular health and cognitive decline and dementia

Dr Colm Cunningham

Wellcome Trust Senior Research Fellow/Research Lecturer | Trinity College Dublin, School of Biochemistry and Immunology & Trinity College

+ 353 1 896 8528
Broad research area Basic Science Research | Clinical Research
Research interests Neuroinflammation, Microglia, Impact of systemic inflammation/co-morbidity on progression of dementia, Delirium.

Dr Damien Thompson

Lecturer and Research Group Leader | University of Limerick

+353-61-234705
Broad research area Basic Science Research
Research interests We are particularly interested in modelling the initial step of the amyloidogenesis cascade and to design small-molecule therapeutics to inhibit critical conformers and/or promote protective pathways. To do this work we use atomic scale simulations (molecular dynamics and quantum mechanics), run on high-performance computing (HPC) platforms. For more on how we model (bio)chemical interactions please visit http://www.energy.ul.ie/research/atom-scale-materials-design-assembled.

Dr Eleanor Mullan

Consultant Psychiatrist, specialising in Older Adults | Cork University Hospital

+353214927266
Broad research area Clinical Research
Research interests Mental Health in Older Adults; Dementia; Depression in Older People

Dr George Kernohan

Professor of Health Research | Ulster University

04890366533
Broad research area Population, Social and Connected Health Research
Research interests Health technology, knowledge transfer and exchange, user involvement, service evaluation

Dr Geraldine Foley

Assistant Professor | Trinity College Dublin

086 8049125
Broad research area Clinical Research | Population, Social and Connected Health Research
Research interests Motor neurone disease, multiple sclerosis, healthcare services for people with neurodegenerative disease

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